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IDH1 (mutant R132H) Rat anti-Human, Clone: OTI3E12, liquid, TrueMAB™
SDP

Rat Monoclonal Antibody

Supplier:  OriGene TA190113

Encompass_Preferred

Catalog No. 50-167-1223


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Description

Description

Isocitrate dehydrogenases such as IDH1 catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predomitly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. This product is specific for IDH1 (mutant R132H).
Specifications

Specifications

IDH1 (mutant R132H)
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
O75874
IDH1
Synthetic peptide around the R132H mutation region of the human IDH conjugated to KLH
100 μL
Primary
Human
Antibody
Western Blot
OTI3E12
Unconjugated
IDH1
IDH1-mutant
Rat
Affinity Chromatography
RUO
3417
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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