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IDH1 (mutant R132H) Rat anti-Human, Clone: OTI3E12, liquid, TrueMAB™

Rat Monoclonal Antibody
Supplier: OriGene TA190113

Description
Isocitrate dehydrogenases such as IDH1 catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predomitly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. This product is specific for IDH1 (mutant R132H).Specifications
IDH1 (mutant R132H) | |
Monoclonal | |
1 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
O75874 | |
IDH1 | |
Synthetic peptide around the R132H mutation region of the human IDH conjugated to KLH | |
100 μL | |
Primary | |
Human | |
Antibody |
Western Blot | |
OTI3E12 | |
Unconjugated | |
IDH1 | |
IDH1-mutant | |
Rat | |
Affinity Chromatography | |
RUO | |
3417 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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