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Invitrogen™ IDH1 (R132H) Recombinant Rabbit Monoclonal Antibody (RM390), Biotin
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Catalog No. PIMA544584
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PIMA544584 50 μL
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Catalog No. PIMA544584 Supplier Invitrogen™ Supplier No. MA544584
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Description

Rabbit Recombinant Monoclonal Antibody

IDH1 (R132H) Recombinant Monoclonal Antibody for IHC (P)

Isocitrate dehydrogenases such as IDH1 catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. This product is specific for IDH1 (mutant R132H).
TRUSTED_SUSTAINABILITY

Specifications

Antigen IDH1 (R132H)
Applications Immunohistochemistry (Paraffin)
Classification Recombinant Monoclonal
Clone RM390
Concentration 100 μg/mL
Conjugate Biotin
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene IDH1
Gene Accession No. O75874
Gene Alias Cytosolic NADP-isocitrate dehydrogenase; epididymis luminal protein 216; epididymis secretory protein Li 26; HEL-216; HEL-S-26; IDCD; IDH; IDH1; IDH1-mutant; IDP; IDPC; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase [NADP] cytoplasmic; isocitrate dehydrogenase 1 (NADP+); isocitrate dehydrogenase 1 (NADP+), soluble; NADP(+)-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal; oxalosuccinate decarboxylase; PICD
Gene Symbols IDH1
Host Species Rabbit
Immunogen A peptide corresponding to human (R132H mutant specific). The immunogen range is a synthetic peptide within amino acids 180-280 of human IDH1 with R132H mutant.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3417
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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