IDH1 Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: OTI24A2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526439
DescriptionIDH1 is a member of the isocitrate deydrogenase family, which catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predomitly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|O75874, O88844, P41562|
|IDH1; isocitrate dehydrogenase 1 (NADP+), soluble; IDCD; IDH; IDP; IDPC; PICD; NADP+-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal; OTTHUMP00000206464; OTTHUMP00000206465; OTTHUMP00000206466; oxalosuccinate decarboxylase|
|-20° C, Avoid Freeze/Thaw Cycles|
|15926, 24479, 3417, 478889, 710019|
|Immunohistochemistry (Paraffin), Western Blot|
|Synthetic peptide around the R132 region of the human IDH conjugated to KLH.|
|Canine, Human, Mouse, Non-human primate, Rat|
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