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IDH1 Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: OTI24A2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526439

Catalog No. PIMA526439


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Description

Description

IDH1 is a member of the isocitrate deydrogenase family, which catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predomitly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.
Specifications

Specifications

IDH1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O75874, O88844, P41562
IDH1; isocitrate dehydrogenase 1 (NADP+), soluble; IDCD; IDH; IDP; IDPC; PICD; NADP+-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal; OTTHUMP00000206464; OTTHUMP00000206465; OTTHUMP00000206466; oxalosuccinate decarboxylase
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
15926, 24479, 3417, 478889, 710019
Immunohistochemistry (Paraffin), Western Blot
OTI24A2
Unconjugated
IDH1
Liquid
IDH1
Synthetic peptide around the R132 region of the human IDH conjugated to KLH.
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Mouse, Non-human primate, Rat
Documents
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