Invitrogen™ IDH3B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589402

Catalog No. PIPA589402

Description

Immunogen sequence: ASRSQAEDVR VEGSFPVTML PGDGVGPELM HAVKEVFKAA AVPVEFQEHH LSEVQNMASE EKLEQVLSSM KENKVAIIGK IHTPMEYKGE LASYDMRLRR KLDLFANVVH VKSLPGYMTR HNNLDLVIIR EQTEGE; Positive Samples: H460, HeLa, 293T, Mouse kidney, Mouse heart, Mouse lung, Rat kidney, Rat heart, Rat lung; Cellular Location: Mitochondrion.

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Specifications

• Antigen: IDH3B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Idh3b
• Gene Alias: C78231; DH3B; H-IDHB; H-IDHG; IDH3B; Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; isocitrate dehydrogenase 3 (NAD(+)) beta; isocitrate dehydrogenase 3 (NAD+) beta; isocitrate dehydrogenase 3 beta; isocitric dehydrogenase subunit beta; N14A tumor-related protein; NAD(+)-specific ICDH subunit beta; NAD+-specific isocitrate dehydrogenase b subunit; RP46
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170718, 3420, 94173
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.53 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O43837, Q68FX0
• Gene Symbols: Idh3b
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 35-170 of human IDH3B (NP_0088302).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG