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Invitrogen™ IDO Polyclonal Antibody
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Catalog No. PIPA585393
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100 μL
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PIPA585393 100 μL
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Catalog No. PIPA585393 Supplier Invitrogen™ Supplier No. PA585393
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Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Predicted reactivity: Rhesus Monkey (97%). Positive Control: A549 (starvation for 24 hr, and 100 ng/mL IFN-gamma treatment for 48 hr), IDO1-transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IDO
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Ido1
Gene Accession No. P14902, Q9ERD9
Gene Alias EC 1.13.11.52; IDO; IDO1; IDO-1; INDO; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine; indoleamine 2,3-dioxygenase 1; indoleamine 23-dioxygenase; Indoleamine-2; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase
Gene Symbols Ido1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human IDO1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3620, 66029
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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