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Invitrogen™ IDO Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA140279

Catalog No. 01-676-398


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Description

Description

PA1-40279 detects Indoleamine 2,3-dioxygenase from human samples. PA1-40279 has been successfully used in ELISA, flow cytometry, immunohistochemistry (paraffin), Western blot, and immunofluorescence applications. A typical starting dilution is 1:50. For Flow cytometry, it is recommended that the polyclonal antibody is used in combination with fixing and permeabilization. The PA1-40279 imunogen is recombinant IDO.

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IDO
Polyclonal
Unconjugated
Ido1
EC 1.13.11.52; IDO; IDO1; IDO-1; INDO; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine; indoleamine 2,3-dioxygenase 1; indoleamine 23-dioxygenase; Indoleamine-2; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase
Sheep
Protein A
RUO
3620
4°C
Liquid
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
P14902
Ido1
Recombinant IDO.
100 μg
Primary
Human
Antibody
IgG
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