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IDO1 Mouse anti-Human, Clone: OTI1E11, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF506378

Encompass_Preferred

Catalog No. 50-166-4287


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregcy, autoimmunity, transplantation, and neoplasia.
Specifications

Specifications

IDO1
Monoclonal
Unconjugated
IDO1
IDO, IDO-1, INDO
Mouse
Affinity Chromatography
RUO
3620
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI1E11
PBS with 8% trehalose and no preservative; pH 7.3
P14902
IDO1
Full length human recombit protein of human IDO1 produced in HEK293T cell.
100 μg
Primary
Human
Antibody
IgG1
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