IDO1 Mouse anti-Human, Clone: OTI1E11, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF506378

Catalog No. 50-166-4287

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregcy, autoimmunity, transplantation, and neoplasia.

Specifications

• Antigen: IDO1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: IDO1
• Gene Alias: IDO, IDO-1, INDO
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3620
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1E11
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P14902
• Gene Symbols: IDO1
• Immunogen: Full length human recombit protein of human IDO1 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1