IDO1 Mouse anti-Human, Mouse, Rat, Clone: 3G2G11, Proteintech

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-6949	Proteintech Group Inc 665281IG150UL	150 μL

Description

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregcy, autoimmunity, transplantation, and neoplasia.

Specifications

• Antigen: IDO1
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: CD107B, IDO, IDO 1, IDO1, INDO, indoleamine 2,3 dioxygenase 1
• Gene Symbols: Ido1
• Isotype: IgG1
• Purification Method: Protein G
• Product Type: Antibody

• Clone: 3G2G11
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P14902, P28776, Q9ERD9
• Gene ID (Entrez): 15930, 3620, 66029
• Immunogen: IDO1 Fusion Protein Ag3953
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: IDO1