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IDO1 Recombinant Rabbit Monoclonal Antibody (BLR031F), Bethyl Laboratories

Catalog No. 501572656
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50-157-2656 10 μL
50-157-2655 100 μL
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Catalog No. 50-157-2656 Supplier Bethyl Laboratories, Inc Supplier No. A700031T
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Description

Rabbit Recombit Monoclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For IHC, epitope retrieval with citrate buffer pH 6.0 is recommende

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregcy, autoimmunity, transplantation, and neoplasia.

Specifications

Antigen IDO1
Applications Immunocytochemistry, Immunohistochemistry, Western Blot
Classification Recombinant Monoclonal
Clone BLR031F
Conjugate Unconjugated
Formulation BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene IDO1
Gene Accession No. P14902
Gene Alias IDO, INDO
Gene Symbols IDO1
Host Species Rabbit
Immunogen recombit protein representing Human IDO1
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3620
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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