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Invitrogen™ Iduronate 2 Sulfatase Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA595962
Description
Immunogen sequence: TDALNVLLII VDDLRPSLGC YGDKLVRSPN IDQLASHSLL FQNAFAQQAV CAPSRVSFLT GRRPDTTRLY DFNSYWRVHA GNFSTIPQYF KENGYVTMSV GKVFHPGISS NHTDDSPYSW SFPPYHPSSE KYENTKTCRG PDGELHANLL CPVDVLDVPE GTLPDKQSTE QAIQLLEKMK TSASPFFLAV GYHKPHIPFR YPKEFQKLYP LENITLAPDP EVPDGLPPVA YNPWMDIRQR EDVQALNISV PYGPIPV; Positive Samples: HepG2, A-549, HT-1080, Mouse kidney, Rat kidney; Cellular Location: Lysosome.
Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.
Specifications
Iduronate 2 Sulfatase | |
Polyclonal | |
Unconjugated | |
Ids | |
alpha-L-iduronate sulfate sulfatase; AW214631; Ids; Iduronate 2-sulfatase; iduronate 2-sulfatase (Hunter syndrome); iduronate 2-sulfatase 14 kDa chain; Iduronate 2-sulfatase 42 kDa chain; iduronate sulfatase; iduronate-2-sulfatase; idursulfase; MPS2; SIDS | |
Rabbit | |
Affinity chromatography | |
RUO | |
15931, 3423, 363513 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
1.72 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P22304, Q08890 | |
Ids | |
Recombinant fusion protein containing a sequence corresponding to amino acids 34-290 of human IDS (NP_0001931). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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