Invitrogen™ Iduronate 2 Sulfatase Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595962

Catalog No. PIPA595962

Description

Immunogen sequence: TDALNVLLII VDDLRPSLGC YGDKLVRSPN IDQLASHSLL FQNAFAQQAV CAPSRVSFLT GRRPDTTRLY DFNSYWRVHA GNFSTIPQYF KENGYVTMSV GKVFHPGISS NHTDDSPYSW SFPPYHPSSE KYENTKTCRG PDGELHANLL CPVDVLDVPE GTLPDKQSTE QAIQLLEKMK TSASPFFLAV GYHKPHIPFR YPKEFQKLYP LENITLAPDP EVPDGLPPVA YNPWMDIRQR EDVQALNISV PYGPIPV; Positive Samples: HepG2, A-549, HT-1080, Mouse kidney, Rat kidney; Cellular Location: Lysosome.

Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.

Specifications

• Antigen: Iduronate 2 Sulfatase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ids
• Gene Alias: alpha-L-iduronate sulfate sulfatase; AW214631; Ids; Iduronate 2-sulfatase; iduronate 2-sulfatase (Hunter syndrome); iduronate 2-sulfatase 14 kDa chain; Iduronate 2-sulfatase 42 kDa chain; iduronate sulfatase; iduronate-2-sulfatase; idursulfase; MPS2; SIDS
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15931, 3423, 363513
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.72 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P22304, Q08890
• Gene Symbols: Ids
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 34-290 of human IDS (NP_0001931).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG