Invitrogen™ IEX-1 Polyclonal Antibody

Catalog No.	Quantity
PIPA560536	100 μL

Catalog No. PIPA560536 Supplier Invitrogen™ Supplier No. PA560536

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MCHSRSCHPT MTILQAPTPA PSTIPGPRRG SGPEIFTFDP L Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 76%.

IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-a. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappa-B/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.

Specifications

• Antigen: IEX-1
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: IER3
• Gene Accession No.: P46695
• Gene Alias: AI663993; anti-death protein; cAMP inducible gene 3; cI-3; DADB-118P11.5; Dif2; DIF-2; differentiation-dependent gene 2 protein; expressed in pancreatic carcinoma; GLY96; gly96, mouse, homolog of; IER3; IEX1; IEX-1; IEX-1L; immediate early protein GLY96; immediate early response 3; immediate early response 3 protein; immediately early gene X-1; Ler3; PACAP-responsive gene 1 protein; PRG1; Protein DIF-2; Protein PRG1; Radiation-inducible immediate-early gene IEX-1
• Gene Symbols: IER3
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human IER3. Recombinant protein control fragment (Product #RP-102947).
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8870
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG