Invitrogen™ IEX-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520391

Catalog No. PIPA520391

Description

A suggested positive control is human brain tissue lysate. PA5-20391 can be used with blocking peptide PEP-0508. Antibodies should not be exposed to prolonged high temperatures.

IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-a. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappa-B/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.

Specifications

• Antigen: IEX-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IER3
• Gene Alias: AI663993; anti-death protein; cAMP inducible gene 3; cI-3; DADB-118P11.5; Dif2; DIF-2; differentiation-dependent gene 2 protein; expressed in pancreatic carcinoma; GLY96; gly96, mouse, homolog of; IER3; IEX1; IEX-1; IEX-1L; immediate early protein GLY96; immediate early response 3; immediate early response 3 protein; immediately early gene X-1; Ler3; PACAP-responsive gene 1 protein; PRG1; Protein DIF-2; Protein PRG1; Radiation-inducible immediate-early gene IEX-1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15937, 8870
• Content And Storage: 4°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P46694, P46695
• Gene Symbols: IER3
• Immunogen: A 24 amino acid peptide near the center of human IEX1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov