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Invitrogen™ IFI35 Polyclonal Antibody
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Catalog No. PIPA565421
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100 μL
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PIPA565421 100 μL
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Catalog No. PIPA565421 Supplier Invitrogen™ Supplier No. PA565421
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VDVRELLPGSV MLGFARDGVA QRLCQIGQFT VPLGGQQVPL RVSPYVNGEI QKAEIRSQPV PRSVLVLNIP DILDGPELHD VLEIHFQKPT RGGGEVEALT VVPQGQQGLA VFTSESG Highest antigen sequence identity to the following orthologs - mouse 76%, rat 77%.

Interferon-Induced Protein 35 (IFI35), encoded by the IFI35 gene, is located on chromosome 17 and is recognized for its role in immune response modulation, especially under viral stress conditions. Structurally, IFI35 is part of a complex regulatory network that influences non-canonical NF-kB signaling. This process involves the proteasomal processing of p105 into the DNA-binding transcription factor p50, which forms a heterodimer with RELB (RELB/p50) to activate cell chemotaxis autonomously. The gene's dynamic expression under viral stress has been linked to various immune regulatory networks and is crucial for immune cell recruitment and maintenance, particularly M2-like tumor-associated macrophages (TAMs) within the tumor microenvironment. IFI35 upregulation is significant in conditions of neuroinflammation and multiple sclerosis, especially in patients treated with interferons (IFN), indicating its potential as a biomolecular marker. Additionally, IFI35's role in triple-negative breast cancer highlights its impact on antitumor immunity, where its ablation enhances the infiltration of effector CD8+ T cells and sensitizes tumors to anti-PD-1 immunotherapy. This positions IFI35 as a key player in both immune response and cancer treatment strategies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IFI35
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene IFI35
Gene Accession No. P80217
Gene Alias 2010008K16Rik; AW986054; IFI35; ifi-35; IFP 35; IFP35; interferon induced protein 35; interferon-induced 35 kDa protein; Interferon-induced 35 kDa protein homolog; interferon-induced protein 35
Gene Symbols IFI35
Host Species Rabbit
Immunogen Recombinant Human IFI35. Recombinant protein control fragment (Product #RP-106104).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3430
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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