IFIT1 Mouse anti-Human, Mouse, Rat, Clone: OTI3G8, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA500948S
DescriptionInterferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5 ft.-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2 ft.-O-methylation of the 5 ft. cap and bear a 5 ft.-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2 ft.-O-methylase for their mRNAs or by stealing host cap containing the 2 ft.-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561|
|-20° C, Avoid Freeze/Thaw Cycles|
|15957, 3434, 56824|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of human IFIT1 produced in HEK293T cell.|
|Human, Mouse, Rat|
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