IFIT1 Mouse anti-Human, Mouse, Rat, Clone: OTI3G8, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA500948S

Catalog No. 50-167-2089

Description

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5′-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2′-O-methylation of the 5′ cap and bear a 5′-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2′-O-methylase for their mRNAs or by stealing host cap containing the 2′-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

Specifications

• Antigen: IFIT1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P09914, Q64282
• Gene Symbols: Ifit1
• Immunogen: Full length human recombit protein of human IFIT1 produced in HEK293T cell.
• Quantity: 30 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI3G8
• Conjugate: Unconjugated
• Gene: IFIT1
• Gene Alias: C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15957, 3434, 56824
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid