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IFIT1 Mouse anti-Human, Mouse, Rat, Clone: OTI3G8, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA500948S

Encompass_Preferred

Catalog No. 50-167-2089


May include imposed supplier surcharges.
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Description

Description

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5′-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2′-O-methylation of the 5′ cap and bear a 5′-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2′-O-methylase for their mRNAs or by stealing host cap containing the 2′-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
Specifications

Specifications

IFIT1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P09914, Q64282
Ifit1
Full length human recombit protein of human IFIT1 produced in HEK293T cell.
30 μL
Primary
Human, Mouse, Rat
Antibody
IgG1
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI3G8
Unconjugated
IFIT1
C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561
Mouse
Affinity Chromatography
RUO
15957, 3434, 56824
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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