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IFIT1 Mouse anti-Human, Mouse, Rat, Clone: OTI3G8, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA500948

Catalog No. 50-167-2088


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Description

Description

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5 ft.-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2 ft.-O-methylation of the 5 ft. cap and bear a 5 ft.-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2 ft.-O-methylase for their mRNAs or by stealing host cap containing the 2 ft.-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
Specifications

Specifications

IFIT1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P09914, Q64282
C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
15957, 3434, 56824
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI3G8
Unconjugated
IFIT1
Liquid
Ifit1
Full length human recombit protein of human IFIT1 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Rat
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