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Invitrogen™ IFIT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA3846

Catalog No. PA3846


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Description

Description

PA3-846 detects ISG56 (p56) from mouse samples. PA3-846 has been successfully used in Western blot applications to detect a 39-58 kDa band.

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IFIT1
Polyclonal
Unconjugated
IFIT1
C56; G10P1; Garg16; GARG-16; glucocorticoid-attenuated response gene 16 product; glucocorticoid-attenuated response gene 16 protein; Ifi56; IFI-56; IFI-56K; IFIT1; IFIT-1; IFNAI1; interferon induced protein with tetratricopeptide repeats 1; interferon, alpha-inducible protein (MW 56kD); interferon-induced 56 kDa protein; Interferon-induced protein with tetratricopeptide repeats 1; interferon-induced protein with tetratricopeptide repeats 1-like protein; interferon-inducible mRNA 561; Isg56; P56; RNM561
Rabbit
100 μL
Primary
Mouse
Antibody
IgG
Western Blot
Conc. Not Determined
whole serum with 0.05% sodium azide
Q64282
IFIT1
aa 217-233 of mouse IFIT1.
RUO
15957
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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