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Invitrogen™ IFITM3 Polyclonal Antibody
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Catalog No. PIPA5143273
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100 μg
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PIPA5143273 100 μg
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Catalog No. PIPA5143273 Supplier Invitrogen™ Supplier No. PA5143273
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Description

Goat Polyclonal Antibody

Additional Information: The immunizing peptide only differs by one residue from IFITM2 and therefore cross-reactivition of this antibody is to be expected. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

IFITM3 (interferon induced transmembrane protein 3), also known as 1-8U or IP15, is a multi-pass membrane protein that belongs to the IFITM (interferon inducible transmembrane) family of proteins. IFITM proteins are induced by type I and type II interferons and contain multiple interferon (IFN)-stimulated response elements (ISREs) in their promoter regions. IFITM proteins play important roles in many cellular processes and their expression requires the presence of the chromatin remodeling SWI/SNF-like BAF complexes. Cellular processes involving IFITM proteins include cellular anti-proliferative activities and homotypic cell adhesion functions of interferons. In addition, IFITM genes are often upregulated in various cancer cells, suggesting a possible role in carcinogenesis. Localizing to the membrane, IFITM3 is a 133 amino acid protein that is induced by IFN-alpha and IFN-gamma. IFITM3 expression can be regulated by TEF-1, Brg-1 and Sp1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IFITM3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene IFITM3
Gene Accession No. Q01628
Gene Alias 1110004C05Rik; 1-8U; Cd225; Cdw217; Dispanin subfamily A member 2b; DSPA2b; Fgls; Fragilis; Fragilis 3; Fragilis protein; Ifitm3; ifitm-like protein 1; interferon induced transmembrane protein 3; interferon-induced transmembrane protein 3; interferon-inducible protein 15; Interferon-inducible protein 1-8U; interferon-inducible protein variant 10; IP15; mil-1; Mouse ifitm-like protein 1; rat8
Gene Symbols IFITM3
Host Species Goat
Immunogen Peptide with sequence C-HNPAPPTSTVIHIRS (aa 36-50).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10410
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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