Invitrogen™ IFN alpha Monoclonal Antibody (RMMA-1)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ 221001

Catalog No. PI221001

Description

221001 targets IFN alpha in ELISA and Neutralization applications and shows reactivity with mouse samples. Purity is greater than 95%, and endotoxin level is less than 1 EU/ug. In neutralization assays, one neutralization unit is the amount of antiserum required to neutralize one unit of mouse IFN alpha to a 50% endpoint. This antibody is expected to work in IP applications, although it has not been fully evaluated for IP. After receipt, the product may be stored at -20C for short-term use (under 6 months). For long-term storage, the product should be kept at -70C or below for retention of full activity. IFN alpha has a predicted molecular weight of approximately 19 kDa.

IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.

Specifications

• Antigen: IFN alpha
• Classification: Monoclonal
• Concentration: 2.5 mg/mL
• Formulation: 0.3M sodium bicarbonate with 0.2M NaCl and no preservative; pH 8.0
• Gene Accession No.: P01572, P01573
• Gene Symbols: IFNA, IFNA1, Ifna15, IFNA2
• Immunogen: mouse interferon alpha.
• Quantity: 250 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Neutralization
• Clone: RMMA-1
• Conjugate: Unconjugated
• Gene: IFNA1
• Gene Alias: alpha-2a interferon; Gm12597; ifa; Ifa1; Ifa2; IFL; IFN; IFN alpha; IFN alpha 1/13; IFN alpha 1b; IFN a; IFN1@; IFNA; IFNA@; IFNA1; IFNA13; Ifna15; Ifna2; IFNA2A; IFNA2B; IFNA2C; IFNA3; IFNA6; Ifnaa; IFNAalphaIFN-alpha-1/13; IFNalpha; IFN-alpha; IFN-alpha 1b; IFN-alpha1; IFN-alpha-1; IFN-alpha-1/13; IFN-alpha-2; IFN-alpha-6; IFN-alphaA; IFN-alphaD; IFN-gamma; IFNa; INFA2; interferon; interferon alpha; interferon alpha 1; Interferon alpha 13 (IFNA13); interferon alpha 15; interferon alpha 1b; interferon alpha 2; interferon alpha 2a; interferon alpha 2b; interferon alpha A; interferon alpha family gene 1; interferon alpha family, gene 2; Interferon alpha leukocyte (IFL); interferon alpha protein; interferon alpha-1; Interferon alpha1 (IFNA1); interferon alpha-1 precursor; interferon alpha-1/13; Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-2; Interferon alpha-A; Interferon alpha-D; Interferon alpha-D (IFN alphaD); interferon type A1/A2; interferon type A3; interferon, alpha 1; interferon, alpha 2; interferon-alpha; interferon-alpha 1; interferon-alpha1; interferon-alpha-6; leIF A; LeIF D; MGC138207; MGC138505; MGC138507; MuIFN-alpha-A; novel interferon alpha (Ifna) family member; OTTMUSG00000007655
• Host Species: Rat
• Purification Method: Affinity chromatography, Ion-exchange chromatography, Size-exclusion chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 111654, 15962, 15965, 242517
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

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