Invitrogen™ IFN beta Monoclonal Antibody (MMHB-1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 214051

Catalog No. PI214051

Description

This antibody is suitable for use in direct ELISA assays. In an A549/EMCV (cell/virus) assay system, this antibody does not neutralize the cytopathic inhibitory effect of human IFN beta. Store at -20°C for short-term use (less than 6 months). For long-term storage, aliquot and store at -70°C or below for retention of full activity. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% BSA. Packaged by and distributed for PBL Assay Science.

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

Specifications

• Antigen: IFN beta
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.1% BSA and no preservative
• Gene Accession No.: P01574
• Gene Symbols: Ifnb1
• Immunogen: human interferon beta.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA
• Clone: MMHB-1
• Conjugate: Unconjugated
• Gene: Ifnb1
• Gene Alias: Fibroblast interferon; Ifb; IFF; IFN b; IFN ß; IFNB; Ifnb1; IFNbeta; IFN-beta; IFNß; Interferon; Interferon b; Interferon beta; interferon beta 1; interferon beta 1, fibroblast; interferon beta protein; interferon, beta 1; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 3456
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid