IFN-γ Mouse anti-Human, APC, Clone: B27, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 562017

Catalog No. BDB562017

Description

The B27 monoclonal antibody specifically binds to human interferon- γ(IFN- γ). IFN-γis a potent multifunctional cytokine that is produced by several activated cell types including NK, NKT, CD4+TCRαβ+, CD8+TCRαβ+, and TCRγδ + T cells. IFN- γexerts i ts biological effects through specific binding to the high-affinity IFN- γReceptor Complex comprised of IFN- γβ subunits. In addition to its antiviral effects, IFN- γupregulates a number of lymphoid cell functions including the antimicrobial and antitumor responses of macrophages, NK cells, and neutrophils. In addition, IFN- γcan exert strong regulatory influences on the proliferation, differentiation, and effector responses of B cell and T cell subsets. Th ese influences can involve IFN- γ’s capacity to boost MHC class I and II expression by antigen-presenting cells as well as to direct effects on B cells and T cells t hemselves. Human IFN-γis a 14- 18 kDa glycoprotein containing 143 amino acid residues. B27 is a neutralizing antibody. The use of B27 antibody for epitope mapping of human IFN- γhas been described. The B27 antibody has been reported not to bind to denatured IFN- γ.

Specifications

• Antigen: IFN-γ
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: IFNG; Interferon-gamma; Interferon-γ; Type II interferon; MAF
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: B27
• Conjugate: APC
• Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
• Immunogen: Human IFN-γ Recombinant Protein
• Quantity: 25 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.