Invitrogen™ IGF1R alpha Monoclonal Antibody (1H7)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA121540

Catalog No. PIMA121540

Description

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of malignant cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.

Specifications

• Antigen: IGF1R alpha
• Classification: Monoclonal
• Concentration: 0.3 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: P08069
• Gene Symbols: Igf1r
• Immunogen: Purified human placental IGF-1 receptors.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Functional Assay, Neutralization, Western Blot, Immunocytochemistry
• Clone: 1H7
• Conjugate: Unconjugated
• Gene: Igf1r
• Gene Alias: A330103N21Rik; CD221; D930020L01; hyft; IGF-1 receptor; Igf1r; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; insulin-like growth factor 1 receptor beta subunit; insulin-like growth factor I receptor; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor; insulin-like growth factor-I receptor precursor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 3480
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid