Invitrogen™ IGF1R (CD221) Recombinant Rabbit Monoclonal Antibody (012), FITC

Catalog No.	Quantity
PIMA546645	100 Tests

Catalog No. PIMA546645 Supplier Invitrogen™ Supplier No. MA546645

Description

Rabbit Recombinant Monoclonal Antibody

Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human IGF1R (CD221) (Met1-Asn932) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

IGF1R, also known as Insulin-like Growth Factor 1 (IGF-1) Receptor, is a receptor tyrosine kinase activated by IGF-1 and IGF-2. IGFR has been implicated in a variety of cancers. The protein is a tetramer consisting of two alpha, and two beta subunits. The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2. Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136. The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation.

Specifications

• Antigen: IGF1R (CD221)
• Applications: Flow Cytometry
• Classification: Recombinant Monoclonal
• Clone: 012
• Concentration: 100 μg/mL
• Conjugate: FITC
• Formulation: PBS with 0.5% BSA and 0.03% ProClin 300
• Gene: IGF1R
• Gene Accession No.: P08069
• Gene Alias: A330103N21Rik; CD221; CD221 antigen; D930020L01; hyft; IGF 1 receptor; IGF 1R; IGF1R; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; Insulin-like growth factor I receptor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2
• Gene Symbols: IGF1R
• Host Species: Rabbit
• Immunogen: Recombinant protein ecoding Human IGF1R (CD221) (Met1-Asn932).
• Purification Method: Protein A
• Quantity: 100 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3480
• Target Species: Human
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG