IGF1R Mouse anti-Human, Clone: OTI11E4, lyophilized, TrueMAB™

Catalog No.	Quantity
50-166-8515	100 μg

Catalog No. 50-166-8515 Supplier OriGene Supplier No. CF807836

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Insulin growth factor 1 receptor belongs to the family of tyrosine receptor kinases. It is involved in activation of various substrates including IGF and neurotensin, regulation of metabolism, cell division, maintece, and inflammation response. The protein is a tetramer consisting of two alpha, and two beta subunits. The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2. Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136. The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation.

Specifications

• Antigen: IGF1R
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI11E4
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: IGF1R
• Gene Accession No.: P08069
• Gene Alias: CD221, IGFIR, IGFR, JTK13
• Gene Symbols: IGF1R
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 741-935 of human IGF1R produced in Insect.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3480
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1