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Invitrogen™ IGF2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA585545
Description
Keep as concentrated solution. Positive Control: HepG2, HepG2 conditioned medium, IGF2-transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
Specifications
IGF2 | |
Polyclonal | |
Unconjugated | |
IGF2 | |
AL033362; C11orf43; FLJ22066; FLJ44734; GRDF; H-IGF-2; IGF; Igf2; Igf-2; IGFII; Igf-II; Insulin like growth factor; insulin like growth factor 2; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); Insulin-like growth factor II Ala-25 Del; insulin-like growth factor II isoform 2 variant 4 preprotein; insulin-like growth factor type 2; M6pr; Mpr; MSA; multiplication-stimulating activity; Multiplication-stimulating polypeptide; Peg2; PP1446; PP9974; preptin; RNIGF2; Somatomedin-A; T3M-11-derived growth factor | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
3481 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
P01344 | |
IGF2 | |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human IGF2. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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