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Invitrogen™ IGF2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585545

Catalog No. PIPA585545


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Description

Description

Keep as concentrated solution. Positive Control: HepG2, HepG2 conditioned medium, IGF2-transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IGF2
Polyclonal
Unconjugated
IGF2
AL033362; C11orf43; FLJ22066; FLJ44734; GRDF; H-IGF-2; IGF; Igf2; Igf-2; IGFII; Igf-II; Insulin like growth factor; insulin like growth factor 2; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); Insulin-like growth factor II Ala-25 Del; insulin-like growth factor II isoform 2 variant 4 preprotein; insulin-like growth factor type 2; M6pr; Mpr; MSA; multiplication-stimulating activity; Multiplication-stimulating polypeptide; Peg2; PP1446; PP9974; preptin; RNIGF2; Somatomedin-A; T3M-11-derived growth factor
Rabbit
Antigen affinity chromatography
RUO
3481
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
P01344
IGF2
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human IGF2.
100 μL
Primary
Human
Antibody
IgG
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