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Invitrogen™ IGF2 Polyclonal Antibody
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Catalog No. PIPA5106909
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100 μL
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PIPA5106909 100 μL
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Catalog No. PIPA5106909 Supplier Invitrogen™ Supplier No. PA5106909
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total IGF2.

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IGF2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene IGF2
Gene Accession No. P01344, P01346, P09535
Gene Alias AL033362; C11orf43; FLJ22066; FLJ44734; GRDF; H-IGF-2; IGF; Igf2; Igf-2; IGFII; Igf-II; Insulin like growth factor; insulin like growth factor 2; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); Insulin-like growth factor II Ala-25 Del; insulin-like growth factor II isoform 2 variant 4 preprotein; insulin-like growth factor type 2; M6pr; Mpr; MSA; multiplication-stimulating activity; Multiplication-stimulating polypeptide; Peg2; PP1446; PP9974; preptin; RNIGF2; Somatomedin-A; T3M-11-derived growth factor
Gene Symbols IGF2
Host Species Rabbit
Immunogen A synthesized peptide derived from human IGF2(Accession P01344), corresponding to amino acid residues E30-L80.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16002, 24483, 3481
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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