Invitrogen™ IGF2 Polyclonal Antibody

Catalog No.	Quantity
PIPA571494	200 μL

Catalog No. PIPA571494 Supplier Invitrogen™ Supplier No. PA571494

Description

Rabbit Polyclonal Antibody

IGF2 Polyclonal Antibody for Flow, IHC (P), Western Blot

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.

Specifications

• Antigen: IGF2
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.45 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: IGF2
• Gene Accession No.: P01344, P09535
• Gene Alias: AL033362; C11orf43; FLJ22066; FLJ44734; GRDF; H-IGF-2; IGF; Igf2; Igf-2; IGFII; Igf-II; Insulin like growth factor; insulin like growth factor 2; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); Insulin-like growth factor II Ala-25 Del; insulin-like growth factor II isoform 2 variant 4 preprotein; insulin-like growth factor type 2; M6pr; Mpr; MSA; multiplication-stimulating activity; Multiplication-stimulating polypeptide; Peg2; PP1446; PP9974; preptin; RNIGF2; Somatomedin-A; T3M-11-derived growth factor
• Gene Symbols: IGF2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide between 39-68 amino acids from the Central region of human IGF2.
• Purification Method: Antigen affinity chromatography, Protein A
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16002, 3481
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG