IGF2BP3 Mouse anti-Human, Clone: OTI7B10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF811489

Catalog No. 50-167-0683

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some maligcies. IMP-3 is expressed in maligt melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of maligt melanoma and may play an important role in the regulation of the biologic behavior of this tumor.

Specifications

• Antigen: IGF2BP3
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: IGF2BP3
• Gene Alias: CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10643
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI7B10
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O00425
• Gene Symbols: IGF2BP3
• Immunogen: Full length human recombit protein of human IGF2BP3 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a