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IGF2BP3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549760

Catalog No. PA549760


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Description

Description

The antibody detects endogenous levels of total IGF2BP3 protein.

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some maligcies. IMP-3 is expressed in maligt melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of maligt melanoma and may play an important role in the regulation of the biologic behavior of this tumor.
Specifications

Specifications

IGF2BP3
Polyclonal
Unconjugated
IGF2BP3
Liquid
IGF2BP3
Synthesized peptide derived from N-terminal of human IGF2BP3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
O00425, Q9CPN8
IMP3, KOC1, VICKZ3
Rabbit
IgG
100 μL
-20°C
Primary
10643, 140488
Documents
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