IGF2BP3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-9610	150 μL

Catalog No. 50-172-9610 Supplier Proteintech Group Inc Supplier No. 146421AP150UL

Description

Rabbit Polyclonal Antibody

Both isoforms (64 kDa and 22 kDa) of IGFBP3 can be recognized by this antibody. IGFBP3 is nuclear and cytoplasmic in staining.

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some maligcies. IMP-3 is expressed in maligt melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of maligt melanoma and may play an important role in the regulation of the biologic behavior of this tumor.

Specifications

• Antigen: IGF2BP3
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.15 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: IGF2BP3
• Gene Accession No.: O00425, Q9CPN8
• Gene Alias: hKOC, IGF II mRNA binding protein 3, IGF2 mRNA binding protein 3, IGF2BP3, IMP 3, IMP3, KOC1, VICKZ family member 3, VICKZ3
• Gene Symbols: IGF2BP3
• Host Species: Rabbit
• Immunogen: IGF2BP3 Fusion Protein Ag6226
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10643, 140488
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG