Invitrogen™ IGFBP5 Monoclonal Antibody (145619)

Catalog No.	Quantity
PIMA523872	100 μg

Catalog No. PIMA523872 Supplier Invitrogen™ Supplier No. MA523872

Description

Mouse Monoclonal Antibody

In ELISAs, this antibody shows 5% cross-reactivity with recombinant mouse (rm) IGFBP-5 and no cross-reactivity with rhIGFBP-2, -3, -4, -6, rmIGFBP-1, -2, -3, -6, rhIGFBP-rp1, rmIGF-I, rmIGF-II, rhIGF-I, or rhIGF-II. In Western blots, this antibody does not cross-react with rhIGFBP-1, -2, -3, -4, -6, or -7. Reconstitute at 0.5 mg/mL in sterile PBS.

The insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. For instance, IGFBP1 is negatively regulated by insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. It has been suggested that IGFBP2 functions as chaperone, escorting IGFs to their target tissues. It is expressed in several human tissues including fetal eye and fetal brain. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury. IGFBP5 is secreted by myoblasts and may play a key role in muscle differentiation.

Specifications

• Antigen: IGFBP5
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 145619
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: IGFBP5
• Gene Accession No.: P24593
• Gene Alias: AI256729; AW208790; IBP 5; IBP5; IBP-5; IGF BP5; IGF-binding protein 5; IGFBP; IGFBP 5; Igfbp5; IGF-BP5; Igfbp-5; IGFBP-5P; Insulin like growth factor binding protein; insulin like growth factor binding protein 5; insulin-like growth factor binding protein 5; insulin-like growth factor binding protein-5; insulin-like growth factor-binding protein 5
• Gene Symbols: IGFBP5
• Host Species: Mouse
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human IGFBP-5 Glu28-Glu272.
• Purification Method: Protein A/G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3488
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1