Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA595895

IGFBP5 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA595895
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA595895 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA595895 Supplier Thermo Scientific Supplier No. PA595895

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Rabbit Polyclonal Antibody

Immunogen sequence: GVYTERCAQG LRCLPRQDEE KPLHALLHGR GVCLNEKSYR EQVKIERDSR EHEEPTTSEM AEETYSPKIF RPKHTRISEL KAEAVKKDRR KKLTQSKFVG Positive Samples: PC-3, BT-474, U-937, Mouse kidney, Mouse skeletal muscle, Mouse lung, Mouse heart

The insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. For instance, IGFBP1 is negatively regulated by insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. It has been suggested that IGFBP2 functions as chaperone, escorting IGFs to their target tissues. It is expressed in several human tissues including fetal eye and fetal brain. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury. IGFBP5 is secreted by myoblasts and may play a key role in muscle differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IGFBP5
Applications Western Blot
Classification Polyclonal
Concentration 0.91 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene IGFBP5
Gene Accession No. P24593, Q07079
Gene Alias AI256729, AW208790, IBP 5, IBP5, IBP-5, IGF BP5, IGF-binding protein 5, IGFBP, IGFBP 5, Igfbp5, IGF-BP5, Igfbp-5, IGFBP-5P, Insulin like growth factor binding protein, insulin like growth factor binding protein 5, insulin-like growth factor binding protein 5, insulin-like growth factor binding protein-5, insulin-like growth factor-binding protein 5
Gene Symbols IGFBP5
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 68-167 of human IGFBP5 (NP_0005901)
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16011, 3488
Target Species Human, Mouse
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.