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Invitrogen™ IGHG1 Polyclonal Antibody
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Catalog No. PIPA5103015
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PIPA5103015 100 μL
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Catalog No. PIPA5103015 Supplier Invitrogen™ Supplier No. PA5103015
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Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total IgG1.

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen IGHG1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene IGHG1
Gene Accession No. P01857
Gene Alias IgG1; IgG3; Igh-4; Ighg; IGHG1; IGHG2; IGHG3; IGHG4; Immunoglobulin heavy chain (gamma polypeptide); immunoglobulin heavy constant gamma 1 (G1m marker); immunoglobulin heavy constant gamma 2 (G2m marker); immunoglobulin heavy constant gamma 3 (G3m marker); immunoglobulin heavy constant gamma 4 (G4m marker); RGD1359539; VH7183
Gene Symbols IGHG1
Host Species Rabbit
Immunogen A synthesized peptide derived from human IGHG1(Accession P01857), corresponding to amino acid residues Q79-K129.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3500
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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