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  6. Invitrogen™ IgM Monoclonal Antibody (II/41), eFluor™ 570, eBioscience™, Invitrogen™ 

Invitrogen™ IgM Monoclonal Antibody (II/41), eFluor™ 570, eBioscience™, Invitrogen™

Catalog No. 41579080
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41-579-080 25 μg
41-579-082 100 μg
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Catalog No. 41-579-080 Supplier Invitrogen™ Supplier No. 41579080
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Description

Rat Monoclonal Antibody

Description: The II/41 monoclonal antibody reacts with the mu heavy chain of mouse IgM. It does not react with other classes of mouse immunoglobulin including IgD, IgG or IgA. IgM is expressed intracellularly, during early stages of B lymphopoiesis, and then on the surface of more mature B cells in the bone marrow and peripheral B cells. Fluorochrome conjugated II/41 can be used as a detection secondary for mouse IgM. Applications Reported: This II/41 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, and immunocytochemistry. Applications Tested: This II/41 antibody has been tested by immunocytochemistry on fixed, differentiated OLN93 cells with O1 (Anti-Oligodendrocyte Marker) primary antibody, and by immunohistochemistry (IHC-P) on FFPE human tonsil with HI98 (Anti-CD15) as the primary antibody. This II/41 antibody can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filter Recommendation: When using this eFluor® 570 antibody conjugate, we recommend a filter that will capture the 570 emission wavelength (for example, Excitation 545/25, 565LP, Emission 605/70). A standard Alexa Fluor® 555 or TRITC filter is acceptable. Excitation: 555 nm; Emission: 570 nm

Mouse IgM is an immunoglobulin M antibody that is produced by B cells in response to an antigen. It is the first antibody produced during an immune response and is the largest immunoglobulin in the serum. Mouse IgM is composed of five heavy chains and five light chains, and it is involved in complement activation and agglutination of antigens. It plays a crucial role in the innate immune response and is important for neutralizing pathogens before the adaptive immune response is fully activated. Mouse IgM is widely used in research and diagnostic applications, including ELISA, Western blotting, and immunohistochemistry.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Mouse IgM
Applications Immunohistochemistry (Frozen), Immunocytochemistry
Classification Monoclonal
Clone II/41
Concentration 0.2 mg/mL
Conjugate eFluor 570
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Ighm
Gene Accession No. P01872
Gene Alias AGM1; AI326478; Igh6; Igh-6; Ighm; Igh-M; Igm; immunoglobulin heavy constant mu; MU; muH; VH
Gene Symbols Ighm
Host Species Rat
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16019
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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