Invitrogen™ IGSF11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561231

Catalog No. PIPA561231

Description

Immunogen sequence: PPKCSSAKAF HTEISSSDNN TLTSSNAYNS RYWSNNPKVH RNTESVSHFS DLGQSFSFHS GNANIPSIYA NGTHLVPGQH KTLVVTANRG SSPQVMSRSN GSVSRKP Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.

Immunoglobulin superfamily member 11 (IGSF11) is a gene located on chromosome 3q13.3, encoding a transmembrane protein that belongs to the immunoglobulin superfamily. IGSF11 is known for its expression in the brain, where it plays a role in neuron-to-neuron adhesion and synaptic organization. The protein is involved in processes such as synapse formation and stabilization, impacting neural connectivity and signaling pathways. IGSF11 is also expressed in other tissues, including the gastrointestinal tract, where it can contribute to cell adhesion functions. Research has linked IGSF11 to cancer biology, as its expression is altered in various cancers, potentially influencing tumor cell adhesion and metastasis. Its role in modulating cell signaling pathways makes it an interesting target for therapeutic interventions in both neurological disorders and cancer. Current studies are focusing on its functional implications in synaptic plasticity and tumor progression, providing valuable insights into IGSF11's diverse biological roles.

Specifications

• Antigen: IGSF11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Igsf11
• Gene Alias: 1700025L02Rik; brain and testis-specific immunoglobin superfamily protein; brain and testis-specific immunoglobulin superfamily protein; BTIGSF; Bt-IGSF; cancer/testis antigen 119; CT119; CXADR like 1; CXADRL1; Igsf11; Igsf13; Immunoglobulin superfamily member 11; immunoglobulin superfamily, member 11; immunoglobulin superfamily, member 13; V-set and immunoglobulin domain containing 3; V-set and immunoglobulin domain-containing protein 3; VSIG3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 152404
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5DX21
• Gene Symbols: Igsf11
• Immunogen: Recombinant protein corresponding to Human IGSF11. Recombinant protein control fragment (Product #RP-98480).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG