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IKK 16, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
10mg
50mg
This item is not returnable. View return policy
1186195-62-9
C28H30ClN5OS
520.092
XFVDIVQCZWDBCW-UHFFFAOYSA-N
ikk 16,ikk-16,ikk-16 hcl,4-1-benzothiophen-2-yl-n-4-4-pyrrolidin-1-yl piperidine-1-carbonyl phenyl pyrimidin-2-amine hydrochloride
56972179
[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;hydrochloride
C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl
This item is not returnable. View return policy
1186195-62-9
C28H30ClN5OS
520.092
XFVDIVQCZWDBCW-UHFFFAOYSA-N
ikk 16,ikk-16,ikk-16 hcl,4-1-benzothiophen-2-yl-n-4-4-pyrrolidin-1-yl piperidine-1-carbonyl phenyl pyrimidin-2-amine hydrochloride
56972179
[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;hydrochloride
C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl

Selective inhibitor of IKK

Selective inhibitor of IκB kinase (IKK) (IC 50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC 50 values are 1.0, 0.5, 0.3 and 0.3 μM respectively). Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

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Quantity 10mg
Formula Weight 520.09
Percent Purity >98%
Chemical Name or Material IKK 16

Recommended Storage : Desiccate at -20°C