IKKi/IKK epsilon Rabbit anti-Human, Unconjugated, Polyclonal, Active Motif™

Catalog No.	Quantity
50-199-3058	100 μg

Catalog No. 50-199-3058 Supplier Active Motif Supplier No. 40957

Description

Rabbit Polyclonal Antibody

Nuclear factor kappa B (NF-kappa-B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity. Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma. A novel molecule in the IKK complex was recently identified and designated IKK-iota/IKK-i. IKK epsilon is required for the activation of NF-kappa-B by PMA and T cell receptors but not by TNF-a and IL-1. IKK-iota/IKK-i message is expressed in a variety of tissues and is inducible by TNF-a, IL-1, and LPS.

Specifications

• Antigen: IKKi/IKK epsilon
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: Lot-Specific
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide; pH 7.5
• Gene: IKBKE
• Gene Accession No.: Q14164
• Gene Alias: AW558201; I-kappa-B kinase epsilon; IKBKE; Ikke; IKK-E; IKKepsilon; IKK-epsilon; Ikki; IKK-i; IKK-related kinase epsilon; Inducible I kappa-B kinase; inducible IkappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of kappaB kinase epsilon; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; RP11-534L20.1
• Gene Symbols: IKBKE
• Host Species: Rabbit
• Immunogen: This Ikki/Ikk epsilon antibody was raised against a synthetic peptide corresponding to amino acid residues 175-188, 525-540, and 567-580 of human Ikki/Ikk epsilon.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9641
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG