IKZF3 Mouse anti-Human, Clone: OTI1E1, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF804235

Catalog No. 50-166-6897

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

IKZF3 is a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

Specifications

• Antigen: IKZF3
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: IKZF3
• Gene Alias: AIO, AIOLOS, ZNFN1A3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22806
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI1E1
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9UKT9
• Gene Symbols: IKZF3
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-301 of human IKZF3 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1