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Invitrogen™ IL-10 Monoclonal Antibody (67232)
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Catalog No. PIMA523757
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500 μg
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Catalog No. Quantity
PIMA523757 500 μg
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Catalog No. PIMA523757 Supplier Invitrogen™ Supplier No. MA523757
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Description

Mouse Monoclonal Antibody

In Western blots, shows approximately 15% cross-reactivity with recombinant mouse IL-10 and less than 2% cross-reactivity with recombinant human IL-10. Reconstitute at 0.5 mg/mL in sterile PBS.

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
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Specifications

Antigen IL-10
Applications ELISA, Western Blot
Classification Monoclonal
Clone 67232
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene IL10
Gene Accession No. P29456
Gene Alias CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Gene Symbols IL10
Host Species Mouse
Immunogen E. coli-derived recombinant rat IL-10 Ser19-Asn178.
Purification Method Protein A/G
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25325
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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