Invitrogen™ IL-10 Monoclonal Antibody (CC320)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA516619

Catalog No. PIMA516619

Description

Membrane permeabilization is required for flow cytometry applications. This product is a low-endotoxin, preservative-free formulation. Endotoxin level is <0.01 EU/ug.

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

Specifications

• Antigen: IL-10
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P43480, Q28374, Q29408
• Gene Symbols: IL10
• Immunogen: Plasmid cDNA encoding bovine IL-10.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Bovine, Sheep, Horse, Goat
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Functional Assay
• Clone: CC320
• Conjugate: Unconjugated
• Gene: IL10
• Gene Alias: CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100034187, 100860746, 281246, 443342
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid