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Invitrogen™ IL-10 Monoclonal Antibody (JES052A5)
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Catalog No. PIMA523796
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500 μg
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PIMA523796 500 μg
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Catalog No. PIMA523796 Supplier Invitrogen™ Supplier No. MA523796
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Description

Rat Monoclonal Antibody

In sandwich ELISAs, less than 8% cross-reactivity with recombinant rat IL-10 and 1% cross-reactivity with recombinant cotton rat IL-10 is observed. In sandwich ELISAs, no cross-reactivity with recombinant human (rh) IL-10, recombinant mouse IL-10 R, rhIL-10 R, recombinant canine IL-10, recombinant feline IL-10, or recombinant porcine IL-10 is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
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Specifications

Antigen IL-10
Applications ELISA, Neutralization, Western Blot
Classification Monoclonal
Clone JES052A5
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene IL10
Gene Accession No. P18893
Gene Alias CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Gene Symbols IL10
Host Species Rat
Immunogen E. coli-derived recombinant mouse IL-10.
Purification Method Protein A/G
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16153
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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