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  6. Invitrogen™ IL-10 Monoclonal Antibody (JES3-12G8), Biotin, eBioscience™, Invitrogen™ 

Invitrogen™ IL-10 Monoclonal Antibody (JES3-12G8), Biotin, eBioscience™, Invitrogen™

Catalog No. 5012172
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50-121-72 500 μg
50-121-71 50 μg
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Catalog No. 50-121-72 Supplier Invitrogen™ Supplier No. 13710985
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Description

Rat Monoclonal Antibody

Description: The JES3-12G8 antibody reacts with human interleukin-10 (IL-10). Applications Reported: The JES3-12G8 antibody has been reported for use in the detection of human IL-10 by ELISA. Applications Tested: The JES3-12G8 antibody has been tested as the detection antibody in a sandwich ELISA for analysis of human Interleukin-10 (IL-10) in combination with the purified JES3-9D7 (14-7108) antibody for capture and recombinant human IL-10 (14-8109) as the standard. A suitable range of concentrations of this antibody for ELISA detection is 0.5-2 μg/mL. A standard curve consisting of doubling dilutions of the recombinant standard over the range of 1000 pg/mL - 8 pg/mL should be included in each ELISA plate. Filtration: 0.2 μm post-manufacturing filtered.

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-10
Applications ELISA
Classification Monoclonal
Clone JES3-12G8
Concentration 0.5 mg/mL
Conjugate Biotin
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene IL10
Gene Accession No. P22301
Gene Alias CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Gene Symbols IL10
Host Species Rat
Purification Method Affinity chromatography
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3586
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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For Research Use Only.

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