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  6. Invitrogen™ IL-15 Recombinant Rabbit Monoclonal Antibody (112), Invitrogen™

Invitrogen™ IL-15 Recombinant Rabbit Monoclonal Antibody (112), Invitrogen™
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Catalog No. PIMA543112
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PIMA543112 100 μL
PIMA543360 50 μL
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Catalog No. PIMA543112 Supplier Invitrogen™ Supplier No. MA543112
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Human IL15/IL-15/Interleukin 15

IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.
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Specifications

Antigen IL-15
Applications ELISA
Classification Recombinant Monoclonal
Clone 112
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene IL15
Gene Accession No. P40933
Gene Alias AI503618; il 15; Il15; IL-15; ILN; Interleukin; interleukin 15; Interleukin15; interleukin-15; MGC9721; M-IL-15
Gene Symbols IL15
Host Species Rabbit
Immunogen Recombinant Human IL15/IL-15/Interleukin 15 Protein.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3600
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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