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  6. Invitrogen™ IL-17F Monoclonal Antibody (SHLR17), Brilliant Ultra Violet™ 395, eBioscience™, Invitrogen™ 

Invitrogen™ IL-17F Monoclonal Antibody (SHLR17), Brilliant Ultra Violet™ 395, eBioscience™, Invitrogen™

Catalog No. 363716941
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36-371-6941 25 Tests
36-371-6942 100 Tests
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Catalog No. 36-371-6941 Supplier Invitrogen™ Supplier No. 363716941
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Description

Rat Monoclonal Antibody

IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production. IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells. IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-17F
Applications Flow Cytometry
Classification Monoclonal
Clone SHLR17
Concentration 5 μL/Test
Conjugate Brilliant Ultraviolet 395
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene IL17F
Gene Accession No. Q96PD4
Gene Alias C87042; CANDF6; cytokine ML-1; IL17F; IL-17F; IL-24; ILN; Interleukin; interleukin 17F; Interleukin17F; interleukin-17F; interleukin-24; ML1; ML-1; mutant IL-17F
Gene Symbols IL17F
Host Species Rat
Purification Method Affinity chromatography
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 112744
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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