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IL-17F Rabbit anti-Mouse, PE, Clone: 1058A, R&D Systems™

Catalog No. IC20571P025
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IC20571P025 25 Tests
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Description

Recombinant Monoclonal Antibody

IL-17F, also called ML-1, is a 21-33kDa member of the IL-17 family of protein. It is one of six glycoproteins with conserved cysteines that form a cystine knot structure. IL-17F is expressed by multiple cell types, including bronchial epthelium, neutrophils (likely), monocytes, mast cells, colonic epithelium, γδ T cells, CD4+ Th17 cells, group 3 (NKp46- RORγt) innate lymphoid cells, NKT cells and CD8+ Tc17 cells. IL-17F is known to form disulfide-linked homodimers, and covalent heterodimes with IL-17A. Notable, the IL-17A and IL-17F homodimers, plus the IL-17A:F heterodimer use the same receptor combination (IL-17RA:IL-17RC), but elicit somewhat different outcomes. For instance, on macrophages, IL-17A induces IL-9, KC and GM-CSF secretion, while IL-17F does not. Both molecules, however, induce the secretion of the same molecules (IL-9, KC, and GM-CSF) by colonic epithelium. Mouse IL-17F has a long form and a short form, which have alternate start sites but identical lengths. Over amino acids (aa) 21-153, mouse IL-17F shares 88% and 56% aa sequence identity with rat and human IL-17F, respectively.

Specifications

Antigen IL-17F
Applications Flow Cytometry
Classification Monoclonal
Clone 1058A
Conjugate R-PE
Dilution Intracellular Staining by Flow Cytometry 10 uL/10^6 cells
Formulation Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide
Gene Accession No. Q7TNI7
Gene Alias Cytokine ML-1, IL17F, IL-17Finterleukin-17F, IL24, IL-24, interleukin 17F, Interleukin-24, ML-1, ML1interleukin-24
Gene Symbols Il17f
Host Species Rabbit
Immunogen E. coli-derived recombinant mouse IL-17F Ala21-Val153 Accession # Q7TNI7
Purification Method Protein A or G purified from cell culture supernatant
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 112744
Test Specificity Detects mouse IL-17F in direct ELISAs.
Target Species Mouse
Content And Storage Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied.
Form Purified
Isotype IgG
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