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Invitrogen™ IL-21 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA546962

Catalog No. PIPA546962


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Description

Description

In sandwich ELISAs, less than 0.5% cross-reactivity with recombinant mouse (rm) IL-2, rmIL-4, rmIL-15, and recombinant human IL-21 is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.30 EU per 1 μg of the antibody by the LAL method.

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IL-21
Polyclonal
Unconjugated
IL21
CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
Goat
Antigen affinity chromatography
RUO
60505
-20°C, Avoid Freeze/Thaw Cycles
Lyophilized
ELISA, Neutralization, Western Blot, Immunocytochemistry
0.2 mg/mL
PBS with 5% trehalose and No Preservative
Q9ES17
IL21
E. coli-derived recombinant mouse IL-21 Pro25-Ser146.
100 μg
Primary
Mouse
Antibody
IgG
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