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Invitrogen™ IL-22 Receptor alpha Polyclonal Antibody
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Catalog No. PIPA519987
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100 μg
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Catalog No. Quantity
PIPA519987 100 μg
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Catalog No. PIPA519987 Supplier Invitrogen™ Supplier No. PA519987
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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~62kDa. A suggested positive control is HepG2 cell lysate. PA5-19987 can be used with blocking peptide PEP-0111.

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
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Specifications

Antigen IL-22 Receptor alpha
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Il22ra1
Gene Accession No. Q8N6P7
Gene Alias 9130219A07Rik; CRF2-9; Cytokine receptor class-II member 9; cytokine receptor family 2 member 9; ENSMUSG00000073746; il-22 receptor; IL-22 receptor subunit alpha-1; IL22R; IL-22R; IL22R1; IL22RA1; IL-22RA1; IL-22R-alpha-1; ILN; Interleukin; interleukin 22 receptor subunit alpha 1; interleukin 22 receptor, alpha 1; interleukin-22 receptor alpha chain; interleukin-22 receptor subunit alpha-1; RGD1559655; zcytoR11
Gene Symbols Il22ra1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to amino acids near the amino terminus of human IL-22 receptor precursor.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 362629, 58985
Target Species Human, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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