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Invitrogen™ IL-22 Receptor alpha Polyclonal Antibody
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Catalog No. PIPA5113903
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100 μL
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PIPA5113903 100 μL
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Catalog No. PIPA5113903 Supplier Invitrogen™ Supplier No. PA5113903
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DQGPSPWGLL ESLVCPKDEA KSPAPETSDL EQPTELDSLF RGLALTVQWE For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 79%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%.

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
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Specifications

Antigen IL-22 Receptor alpha
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene Il22ra1
Gene Accession No. Q8N6P7
Gene Alias 9130219A07Rik; CRF2-9; Cytokine receptor class-II member 9; cytokine receptor family 2 member 9; ENSMUSG00000073746; il-22 receptor; IL-22 receptor subunit alpha-1; IL22R; IL-22R; IL22R1; IL22RA1; IL-22RA1; IL-22R-alpha-1; ILN; Interleukin; interleukin 22 receptor subunit alpha 1; interleukin 22 receptor, alpha 1; interleukin-22 receptor alpha chain; interleukin-22 receptor subunit alpha-1; RGD1559655; zcytoR11
Gene Symbols Il22ra1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the middle region of human IL22RA1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 58985
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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