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MilliporeSigma™ IL-22RA-1, Rabbit, Unlabeled, Polyclonal,

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ 061077I

Catalog No. 061077IMI


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Description

Description

Interleukin-22 receptor subunit alpha-1 (UniProt Q8N6P7; also known as CRF2-9, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, ZcytoR11) is encoded by the IL22RA1 (also known as IL22R) gene (Gene ID 58985) in human. IL-22RA-1 is a member of the type II cytokine receptor family that complexes with IL-10RB and mediates JAK/STAT signaling. IL22 binding to heterodimer is greater than binding to IL22RA1 alone. IL-22RA-1 is expressed in colon, liver, lung, pancreas and kidney, however, no expression is observed in immune cells, such as monocytes, T-cells, and NK-cells. It is also detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions. Higher expression has been observed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.
Specifications

Specifications

IL-22RA-1
Please refer to lot specific datasheet.
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Q8N6P7
Rabbit
Affinity Purified
RUO
Stable for 1 year at 2°-8°C from date of receipt.
Polyclonal
This polyclonal antibody targets a C-terminal sequence within the cytoplasmic domain of human IL-22 receptor subunit alpha-1.
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
IL22RA1, IL22R
Affinity Purified
KLH-conjugated linear peptide corresponding to a sequence within the C-terminal region of human IL-22RA-1 cytoplasmic domain.
100μg
Inflammation & Immunology
Primary
NP_067081
Human, Mouse
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