Invitrogen™ IL-23 p19 Monoclonal Antibody (320234)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA523793

Catalog No. PIMA523793

Description

This antibody recognizes an epitope in the p19 subunit. In ELISAs, this antibody does not cross-react with recombinant mouse (rm) IL-23 p19, rmIL-23 R, rmIL-12 R beta, rmIL-12 p35, recombinant human (rh) IL-23, rhIL-23 p19, recombinant rat IL-12, rmIL-12 p40, rmIL-12 p40 homodimer, or rmIL-12. Reconstitute at 0.5 mg/mL in sterile PBS.

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN-γ. Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naive and memory T cells, as compared to IL-12.

Specifications

• Antigen: IL-23 p19
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9EQ14
• Gene Symbols: IL23A
• Immunogen: E. coli-derived recombinant mouse IL-23.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Western Blot
• Clone: 320234
• Conjugate: Unconjugated
• Gene: IL23A
• Gene Alias: il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 83430
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized