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IL-23R Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501983306
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Catalog No. Quantity
50-198-3306 100 μL
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Catalog No. 50-198-3306 Supplier Bioss Supplier No. BS1460R
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Description

Rabbit Polyclonal Antibody

IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.

Specifications

Antigen IL-23R
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Il23r
Gene Accession No. Q5VWK5
Gene Alias IBD17; IL 23R; IL-23 receptor; Il23r; IL-23R; interleukin 23 receptor; interleukin 23 receptor-like; Interleukin-23 receptor
Gene Symbols Il23r
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human IL-23R.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 149233
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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